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Barcelona & Italy Itinerary - 2 Weeks in December

Over December, my wife and I will be taking a dream trip for us for about 16 days in Spain and Italy. Here is our rough itinerary.

Friday Dec 19 Fly to Barcelona

Saturday Dec 20 Arrive in Barcelona mid-day

Sunday Dec 21 Barcelona

Monday Dec 22 Barcelona

Tuesday Dec 23 AM Flight to Venice/Venezia

Wednesday Dec 24 Venice/Venezia PM Train to Vernazza – 394 Kilometers

Thursday Dec 25 Vernazza

Friday Dec 26 AM Train to Florence/Firenze – 179 Kilometers

Saturday Dec 27 Florence/Firenze

Barcelona or Rome

My wife and I are spending two weeks in Italy and Spain this December. It’s the only possible window for us. We are looking to primarily see Barcelona in Spain, although we are considering multiple stops in Italy.

1) Is it best to fly into Barcelona or Rome?

2) Once there, what is the most effective and enjoyable way to get between Italy and Barcelona for two people? Should we fly? If so, how much should budget per flight? Should we take a ferry or train? We want it to be enjoyable, though we do not want to sacrifice too much of our trip’s time or budget getting between the two.